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Bhupathi, who has seven Grand Slam mixed doubles titles, has paired up with the experienced American Liezel Huber and they have received top billing. The pair will open against American Vania King and Marcelo Melo of Brazil.
Sania has entered the event with 37-year old doubles specialist Daniel Nestor from Canada and the duo are are in the same half as Bhupathi-Huber. Sania and Nestor will meet Akgul Amanmuradova of Uzbekistan and Australian Ashley Fisher in the first round.
Sania's wrist injury had kept her out of action for the most part of 2008 that saw her career ranking drop from a high of 27.
The 74th-ranked Indian was blanked out of the US Open singles second round by Italian Flavia Pennetta Tuesday.
Meanwhile, Leander Paes has teamed up with Cara Black of Zimbabwe and the duo are seeded second. They will play Switzerland's Patty Schnyder and South African Wesley Moodie in the first round.