Sources at Chennai's Neta Hospital, where Balakrishnan was admitted, said the boy had been hospitalised with fever and diarrhoea last week. Later, he was diagnosed with kidney failure and chest congestion.
On Sunday, he suffered multiple organ failure and was put on ventilator. The boy died Monday morning and is the first swine flu death in Tamil Nadu.
Tamil Nadu Health Secretary V.K. Subbaraj told reporters that the residential area where the boy lived had been desanitised and there was adequate stock of the drug Tamiflu.
'The area where the boy lives is where 100 more families are living...we are sanitising the area. There is enough stock of Tamiflu in the state,' Subbaraj said.
India's first swine flu victim was 14-year-old Reeda Shaikh who died Aug 3.
On Sunday, the union health ministry had said the total number of people infected by the virus in the country was 864. Of these, 523 have been discharged from hospital.