He and his wife had tested positive for swine flu Saturday.
Patel succumbed to the virus at the civil hospital in the Gujarat city.
'The NRI, who came from Atlanta, has died of swine flu. This is the first swine flu death in Ahmedabad. The patient had earlier complications as well - he had viral pneumonia, which is very difficult to treat, his haemoglobin was low. All these outer problems added to the complications of swine flu and he passed away,' Gujarat Health Minister Jaynarayan Vyas told IANS.
On Saturday evening, a 53-year old woman, Fahmida Paanwala, died of swine flu in Mumbai's Kasturba Hospital. On Aug 3, a 14-year old girl, Reeda Shaikh, died in Pune. She was the country's first swine flu fatality.
Medical authorities are closely monitoring the condition of three other people - a medico and a pharmacist, who are in critical condition in Pune, and a 28-year-old businessman lying critical in a Mumbai suburban hospital.