Barca have won their first two games and are joint top with Real Madrid, Valencia and Athletic Bilbao.
Also on Saturday, Sevilla, who beat Unirea Urziceni 2-0 in their Champions League debut on Wednesday, are away to Osasuna. Malaga take on Racing Santander, Mallorca face Tenerife and Deportivo Coruna play hosts to Espanyol.
The big game on Sunday sees Real Madrid at home to tiny Xerez.
This is Xerez' first ever season in the top flight and they are already shipping water, having lost both opening games without scoring a single goal.
'We know that we will have a mountain to climb in Madrid,' said goalkeeper Renan. 'But you never can take anything for granted in football.'
Real will be without anchorman Xabi Alonso, who damaged his right heel in Tuesday's spectacular 5-2 win away to Zurich, in which Cristiano Ronaldo scored two more goals.
Valencia will be at home to Sporting Gijon and Bilbao take on Valladolid. Sunday's other games are Zaragoza vs Valladolid and Almeria vs Getafe.